Multi-axis scoring framework that ranks programmable genome editors across eight orthogonal axes into a single PenScore to guide experimental design and benchmarking.

Knowledge graph and GNN benchmark for programmable genome-writing enzymes, with ESM-2 embeddings, GraphSAGE/GAT link prediction, and an editor-selection API.

Two-tier classifier for the catalytic mechanism of programmable genome-writing enzymes, with a biochemical gate that correctly labels IS110-family composite recombinases.