Make rss_analysis.ipynb the GWAS RSS fine-mapping workflow#1378
Merged
Conversation
Ports the 4-step manifest -> construct -> fine_mapping -> plot workflow into rss_analysis.ipynb (replacing the legacy univariate_rss two-step) and removes the duplicate gwas_rss_fine_mapping.ipynb. Repoints the remaining doc references. Co-Authored-By: Claude Opus 4.8 <noreply@anthropic.com>
This file contains hidden or bidirectional Unicode text that may be interpreted or compiled differently than what appears below. To review, open the file in an editor that reveals hidden Unicode characters.
Learn more about bidirectional Unicode characters
Sign up for free
to join this conversation on GitHub.
Already have an account?
Sign in to comment
Add this suggestion to a batch that can be applied as a single commit.This suggestion is invalid because no changes were made to the code.Suggestions cannot be applied while the pull request is closed.Suggestions cannot be applied while viewing a subset of changes.Only one suggestion per line can be applied in a batch.Add this suggestion to a batch that can be applied as a single commit.Applying suggestions on deleted lines is not supported.You must change the existing code in this line in order to create a valid suggestion.Outdated suggestions cannot be applied.This suggestion has been applied or marked resolved.Suggestions cannot be applied from pending reviews.Suggestions cannot be applied on multi-line comments.Suggestions cannot be applied while the pull request is queued to merge.Suggestion cannot be applied right now. Please check back later.
Ports the 4-step GWAS RSS workflow (manifest -> construct -> fine_mapping -> plot) into rss_analysis.ipynb, replacing the legacy univariate_rss two-step, and removes the now-duplicate gwas_rss_fine_mapping.ipynb. Repoints the four remaining doc references.
Depends on the pecotmr harmonization SNP re-key fix (branch harmonize-rekey-snp): the slalom/dentist/kriging QC modes need it to handle sign-flipped variants. Validated end-to-end on the protocol_example chr22 MWE — noQC and slalom+impute reproduce the legacy output/rss_analysis variant set and lead.