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williamtbarker/README.md

Will Barker

Computational scientist building reliable research software at the intersection of bioinformatics, scientific data, machine learning, and systems engineering. I work primarily in Python, Rust, Bash, and SQL, with domain experience spanning influenza virology, viral genomics, drug discovery, and omics analysis.

I am also the founder of SignalForge Advisors and a science-fiction author interested in complex technological systems and their human consequences.

Featured research software

Project What it does
Virustic2 Deterministic, quality-aware de Bruijn assembly in Rust
Stabilomics Robust LAD-LASSO stability selection for scientific feature tables
Antigenic Audit Leakage and temporal-claim auditing for influenza antigenicity models
RefAudit Audits downstream sensitivity to reference-genome choice
SeqSketch Deterministic MinHash/LSH sequence indexing and similarity graphs
BenchLog Local, inspectable experiment tracking and artifact provenance

How I build

My public projects emphasize deterministic behavior, strict input validation, automated tests, reproducible examples, explicit scientific limitations, and interfaces that can be inspected rather than trusted opaquely.

Some projects use AI-assisted research and development. Releases are human-reviewed, locally verified, and accompanied by honest development and validation records.

Elsewhere

  • Professional website
  • LinkedIn
  • Independent consulting through SignalForge Advisors
  • Science-fiction projects including SOFTMAX, The Orchard, and The Gospel According to Greg

Pinned Loading

  1. antigenic-audit antigenic-audit Public

    Python CLI that detects entity leakage, reversed-role leakage, and temporal overclaiming in influenza antigenicity evaluations.

    Python

  2. benchlog benchlog Public

    Local Python experiment tracker with atomic manifests, metric comparison, artifact hashing, and Git provenance.

    Python

  3. refaudit refaudit Public

    Rust CLI that audits how reference-genome choice changes agreement, ranks, signs, status calls, and top-k bioinformatics results.

    Rust

  4. seqsketch seqsketch Public

    Deterministic Python MinHash/LSH sequence search with exact Jaccard reranking and time-directed similarity graphs.

    Python

  5. stabilomics stabilomics Public

    Python CLI for robust, deterministic LAD-LASSO stability selection in high-dimensional genomics and scientific tables.

    Python

  6. virustic2 virustic2 Public

    Deterministic Rust de Bruijn assembler for streamed gzip FASTA/FASTQ, with quality filtering and paired-end/multi-lane support.

    Rust