engineered-biology

Playground Global is an early-stage deep tech venture capital firm founded in 2015 by Andy Rubin, Bruce Leak, Matt Hershenson, and Peter Barrett, and headquartered at 380 Portage Ave, Palo Alto, California.

NVision Imaging Technologies (now operating as NVision Quantum Technologies) is a deep-tech healthcare company that engineers quantum technology at the molecular level. Its flagship POLARIS platform delivers quantum-enhanced MRI, boosting the magnetic signal of engineered sugar molecules by over 10,000x to image disease metabolism in real time…

Insamo is a biotechnology company building membrane-permeable, orally available cyclic peptides that combine the binding affinity of antibodies with the pharmacology of small molecules for drug discovery.

Manifold Bio is a biotechnology company developing tissue-targeted biologic medicines. It runs a high-throughput in vivo discovery engine that pairs massively multiplexed in vivo screening — using mCode protein barcodes read out by DNA sequencing — with AI-powered protein and antibody design (mBER) and engineered mShuttle delivery vehicles.

1910 Genetics (now branded 1910) is an AI-native biotechnology company advancing small and large molecule drug discovery with a multimodal AI platform powered by high-throughput laboratory automation.

Infinimmune is a biotechnology company that discovers and engineers human-derived antibody therapeutics. Its Complete Human Sequencing and Anthrobody library-on-B-cell platform surface rare antibodies that evolution has already proven in people, and its GLIMPSE antibody language model characterizes and optimizes candidates in silico for clinical…

Synthetic Design Lab is a clinical-stage biotechnology company founded in 2022 developing next-generation antibody-drug conjugates (ADCs) for cancer therapy. Its SYNTHBODY platform and SYNTHBODY Engine engineer multispecific biologics with layered BIO-LOGIC control mechanisms and targeted payload delivery reported at 10x or more versus…

GigaCrop is an agricultural biotechnology company engineering the photosynthesis pathway to dramatically increase crop productivity. Founded by Chris Eiben, PhD, the company combines enzyme engineering and machine learning to optimize the RuBisCo enzyme, aiming to roughly double yields in staple crops such as corn and soy and to break past the…

Amber Bio is a San Francisco biotechnology company developing an RNA-based gene-editing platform capable of making multi-kilobase edits — rewriting thousands of bases on a single RNA strand in one step — to reach previously undruggable patient populations.

Outpace Bio is a clinical-stage biotechnology company applying AI-powered protein design to cell therapy, with the mission of curing solid tumors. The company engineers novel proteins that reprogram immune cells to overcome the limitations of current cancer immunotherapies, built on a set of proprietary platform technologies (OUTSPACER, OUTSMART…