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VPopMIP.jl

Virtual population (VPop) selection for Quantitative Systems Pharmacology (QSP) using mixed-integer optimization.

Build Status Dev

⚠️ This package is under development.

Why this package?

VPopMIP.jl implements a cohort-selection workflow where a large plausible population is filtered into a smaller virtual population that matches reported clinical results (summary statistics and individual patients data). The approach is formulated as a mixed-integer programming (MIP) problem and is designed for practical QSP calibration workflows.

Installation

using Pkg
Pkg.add(url="https://github.com/hetalang/VPopMIP.jl")

Citation

E. Metelkin and I. Borisov, “Mixed-Integer Optimization for Virtual Population Selection in QSP Models,” 2026, doi: 10.13140/RG.2.2.31274.79049.

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Virtual Population selection algorithm

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