Skip to content

Add Reuben Addison 2026 intern spotlight #6

New issue

Have a question about this project? Sign up for a free GitHub account to open an issue and contact its maintainers and the community.

Sign up for GitHub

By clicking “Sign up for GitHub”, you agree to our terms of service and privacy statement. We’ll occasionally send you account related emails.

Already on GitHub? Sign in to your account

Open
reubebe wants to merge 1 commit into
base: main
Choose a base branch
from
Open

Add Reuben Addison 2026 intern spotlight #6

Show file tree
Hide file tree
Changes from all commits
Commits
Show all changes
1 commit
Select commit
File filter

Filter by extension

Filter by extension
Conversations
Failed to load comments.
Loading
Jump to
Jump to file
Failed to load files.
Loading
Diff view
Diff view
Binary file modified assets/img/people/reuben-addison.jpg
View file
Open in desktop
Loading
Sorry, something went wrong. Reload?
Sorry, we cannot display this file.
Sorry, this file is invalid so it cannot be displayed.
373 changes: 373 additions & 0 deletions people/reuben-addison.html
View file
Open in desktop
Original file line number Diff line number Diff line change
@@ -0,0 +1,373 @@
<!doctype html>
<html lang="en">
<head>
<meta charset="utf-8" />
<meta name="viewport" content="width=device-width,initial-scale=1" />
<title>Reuben N. Addison, Ph.D. — DS4CABS Summer Intern</title>
<meta name="description" content="Reuben N. Addison, Ph.D. — clinical research scientist, quantitative researcher, and DS4CABS 2026 Summer Intern. Developer of OpenTrial, a Bayesian clinical trial design engine." />
<meta name="theme-color" content="#0b1020" />

<meta property="og:title" content="Reuben N. Addison, Ph.D. — DS4CABS 2026 Summer Intern" />
<meta property="og:description" content="Clinical research scientist and quantitative researcher. Developer of OpenTrial, a Bayesian clinical trial design engine." />
<meta property="og:type" content="profile" />
<meta property="og:url" content="https://ds4cabs.github.io/people/reuben-addison.html" />
<meta property="og:image" content="https://ds4cabs.github.io/assets/img/people/reuben-addison.jpg" />

<link rel="preconnect" href="https://fonts.googleapis.com">
<link rel="preconnect" href="https://fonts.gstatic.com" crossorigin>
<link href="https://fonts.googleapis.com/css2?family=Inter:wght@400;500;600;700;800&family=JetBrains+Mono:wght@400;500&display=swap" rel="stylesheet">

<link rel="stylesheet" href="../assets/css/style.css" />
<link rel="icon" href="data:image/svg+xml,%3Csvg xmlns='http://www.w3.org/2000/svg' viewBox='0 0 100 100'%3E%3Cdefs%3E%3ClinearGradient id='g' x1='0' x2='1' y1='0' y2='1'%3E%3Cstop offset='0' stop-color='%2310b981'/%3E%3Cstop offset='1' stop-color='%236366f1'/%3E%3C/linearGradient%3E%3C/defs%3E%3Crect width='100' height='100' rx='22' fill='url(%23g)'/%3E%3Ctext x='50' y='62' font-family='Inter,Arial' font-size='42' font-weight='800' text-anchor='middle' fill='white'%3EDS%3C/text%3E%3C/svg%3E" />

<style>
.profile-hero { padding-top: 56px; padding-bottom: 56px; }
.profile-card {
display: grid;
grid-template-columns: 168px 1fr;
gap: 32px;
align-items: center;
}
.profile-photo {
width: 168px;
height: 168px;
border-radius: 24px;
overflow: hidden;
background: var(--grad);
border: 1px solid var(--border-strong);
box-shadow: var(--shadow-md);
}
.profile-photo img {
width: 100%;
height: 100%;
object-fit: cover;
display: block;
}
.profile-name {
font-size: clamp(1.8rem, 3.5vw, 2.6rem);
margin-bottom: 6px;
}
.profile-title {
font-size: 1.08rem;
color: var(--text-dim);
margin: 0 0 4px;
font-weight: 600;
}
.profile-org {
color: var(--text-mute);
margin: 0 0 16px;
}
.profile-actions {
display: flex;
flex-wrap: wrap;
gap: 10px;
}
.profile-actions .btn { font-size: .9rem; }

.profile-body {
max-width: 820px;
margin: 0 auto;
}
.profile-section { margin-bottom: 40px; }
.profile-section h3 {
font-size: 1.25rem;
margin-bottom: 14px;
padding-bottom: 8px;
border-bottom: 1px solid var(--border);
}
.profile-section p {
font-size: 1.02rem;
line-height: 1.7;
}

.timeline {
list-style: none;
padding: 0;
margin: 0;
display: grid;
gap: 18px;
}
.timeline li {
padding: 16px 18px;
background: var(--surface);
border: 1px solid var(--border);
border-radius: var(--radius);
}
.timeline .ti-role {
font-weight: 700;
color: var(--text);
}
.timeline .ti-org { color: var(--text-dim); }
.timeline .ti-when {
display: block;
color: var(--text-mute);
font-size: .85rem;
margin-top: 4px;
font-family: var(--mono);
}

.pill-list {
display: flex;
flex-wrap: wrap;
gap: 8px;
margin: 0;
padding: 0;
list-style: none;
}
.pill-list li {
padding: 6px 13px;
border-radius: 999px;
background: var(--surface-2);
border: 1px solid var(--border);
color: var(--text-dim);
font-size: .85rem;
font-weight: 500;
}

.result-card {
padding: 18px 20px;
margin-top: 16px;
background: var(--surface);
border: 1px solid var(--border);
border-radius: var(--radius);
}
.result-card strong { color: var(--text); }

.back-link { margin-bottom: 22px; }

@media (max-width: 640px) {
.profile-card {
grid-template-columns: 1fr;
gap: 20px;
text-align: center;
}
.profile-photo { margin: 0 auto; }
.profile-actions { justify-content: center; }
}
</style>
</head>
<body>

<svg width="0" height="0" style="position:absolute" aria-hidden="true" focusable="false">
<defs>
<linearGradient id="brandGrad" x1="0" x2="1" y1="0" y2="1">
<stop offset="0" stop-color="#10b981"/>
<stop offset="1" stop-color="#6366f1"/>
</linearGradient>
</defs>
</svg>

<!-- ============= NAV ============= -->
<header class="nav">
<div class="container nav-inner">
<a class="brand" href="../index.html" aria-label="DS4CABS home">
<span class="logo" aria-hidden="true">
<svg viewBox="0 0 100 100" width="34" height="34">
<rect width="100" height="100" rx="22" fill="url(#brandGrad)"/>
<text x="50" y="62" font-family="Inter,Arial" font-size="42" font-weight="800" text-anchor="middle" fill="white">DS</text>
</svg>
</span>
<span class="brand-text">
<strong>DS4CABS</strong>
<small>Chinese American Biopharmaceutical Society</small>
</span>
</a>

<button class="nav-toggle" id="navToggle" aria-label="Open menu" aria-expanded="false" aria-controls="navMenu">
<svg class="icon-menu" width="22" height="22" viewBox="0 0 24 24" fill="none" stroke="currentColor" stroke-width="2" stroke-linecap="round" aria-hidden="true"><line x1="3" y1="6" x2="21" y2="6"/><line x1="3" y1="12" x2="21" y2="12"/><line x1="3" y1="18" x2="21" y2="18"/></svg>
<svg class="icon-close" width="22" height="22" viewBox="0 0 24 24" fill="none" stroke="currentColor" stroke-width="2" stroke-linecap="round" aria-hidden="true"><line x1="18" y1="6" x2="6" y2="18"/><line x1="6" y1="6" x2="18" y2="18"/></svg>
</button>

<nav class="nav-links" id="navMenu" aria-label="Primary">
<a href="../index.html#featured">Featured</a>
<a href="../trending.html">Trending</a>
<a href="../team.html" aria-current="page">Team</a>
<a href="../cohort.html">Cohorts</a>
<a href="../index.html#join">Apply</a>
<a href="../index.html#projects">Projects</a>
<a href="../index.html#donation">Donation</a>
<a href="../index.html#about">About</a>
<a class="btn btn-ghost" href="https://github.com/ds4cabs" target="_blank" rel="noopener">GitHub</a>
<button class="theme-toggle" id="themeToggle" aria-label="Toggle color theme" title="Toggle color theme">
<svg class="icon-sun" width="18" height="18" viewBox="0 0 24 24" fill="none" stroke="currentColor" stroke-width="2" stroke-linecap="round" stroke-linejoin="round" aria-hidden="true"><circle cx="12" cy="12" r="4"/><path d="M12 2v2M12 20v2M4.93 4.93l1.41 1.41M17.66 17.66l1.41 1.41M2 12h2M20 12h2M4.93 19.07l1.41-1.41M17.66 6.34l1.41-1.41"/></svg>
<svg class="icon-moon" width="18" height="18" viewBox="0 0 24 24" fill="none" stroke="currentColor" stroke-width="2" stroke-linecap="round" stroke-linejoin="round" aria-hidden="true"><path d="M21 12.79A9 9 0 1 1 11.21 3 7 7 0 0 0 21 12.79z"/></svg>
</button>
</nav>
</div>
</header>

<!-- ============= HERO ============= -->
<section class="section profile-hero">
<div class="container">
<div class="back-link">
<a class="link-arrow" href="../team.html">← Back to the team</a>
</div>

<span class="chip chip-accent">DS4CABS · 2026 Summer Intern</span>

<div class="profile-card">
<div class="profile-photo">
<img src="../assets/img/people/reuben-addison.jpg" alt="Portrait of Reuben N. Addison" />
</div>

<div>
<h1 class="profile-name">Reuben N. Addison, Ph.D.</h1>
<p class="profile-title">Clinical Research Scientist · Quantitative Researcher</p>
<p class="profile-org">DePauw University · DS4CABS 2026 Summer Intern</p>

<div class="profile-actions">
<a class="btn btn-primary" href="https://www.linkedin.com/in/rnaddison/" target="_blank" rel="noopener">LinkedIn ↗</a>
<a class="btn btn-ghost" href="https://github.com/reubebe" target="_blank" rel="noopener">GitHub ↗</a>
<a class="btn btn-ghost" href="https://github.com/ds4cabs/OpenTrial" target="_blank" rel="noopener">OpenTrial ↗</a>
<a class="btn btn-ghost" href="https://reubebe.github.io/" target="_blank" rel="noopener">Personal site ↗</a>
<a class="btn btn-ghost" href="mailto:reuben.addison@gmail.com">Email</a>
</div>
</div>
</div>
</div>
</section>

<!-- ============= BODY ============= -->
<section class="section section-alt">
<div class="container">
<div class="profile-body">

<div class="profile-section">
<h3>About</h3>
<p>
Reuben Addison is a clinical research scientist and quantitative researcher working at the
intersection of study design, Bayesian statistics, and biomedical data science. His work
focuses on making the assumptions behind scientific and clinical decisions explicit,
traceable, and testable.
</p>
<p>
His research spans Parkinson's disease, longitudinal clinical outcomes, cardiovascular
risk, movement science, and clinical trial design. He is an Assistant Professor of
Kinesiology and Director of the Motor Control Lab at DePauw University, holds a Ph.D. in
Motor Behavior, and completed the Computational Data Analytics Track, the data science
track, of Georgia Tech's M.S. in Analytics.
</p>
</div>

<div class="profile-section">
<h3>CABS Internship Project</h3>
<p>
During the 2026 CABS Data Science Summer Internship, Reuben developed
<strong>OpenTrial</strong>, a Bayesian clinical trial design engine under the mentorship
of Prof. Shicheng Guo.
</p>
<p>
OpenTrial starts with a treatment and endpoint, gathers relevant public evidence, and
produces a traceable study-design report. It integrates sources including
ClinicalTrials.gov, PubMed, openFDA, DailyMed, Open Targets, PharmGKB, and Semantic
Scholar, then connects that evidence to power, assurance, prior-sensitivity analysis,
predictive probability of success, and simulation-based design calculations.
</p>
<p>
The central rule is simple: only evidence with a quantifiable effect size and associated
standard error is allowed to update the prior. Other records remain visible for provenance,
but they do not quietly influence the mathematics.
</p>
</div>

<div class="profile-section">
<h3>Validation and Sensitivity Analysis</h3>
<p>
Reuben treated validation as part of the research problem, not as a final software check.
OpenTrial includes 100 offline tests and 46 independent validation checks against SciPy,
statsmodels, closed-form calculations, and separately written Monte Carlo implementations.
</p>
<p>
That process exposed implementation problems that ordinary unit testing had missed,
including a Type I error calculation that appeared correct because calibration and
evaluation had reused the same simulated paths, and a heterogeneity calculation that
double-counted sampling error. Both were corrected.
</p>
<div class="result-card">
<strong>Type I error:</strong> 0.0234 against a 0.025 target.
</div>
<div class="result-card">
<strong>Prior sensitivity:</strong> in a seeded Type 2 diabetes example, the same
80-patient-per-arm design produced an estimated probability of success of 0.87 under the
evidence-derived prior and 0.18 under a skeptical prior. The design did not change. The
assumption did.
</div>
</div>

<div class="profile-section">
<h3>Areas of Focus</h3>
<ul class="pill-list">
<li>Clinical trial design</li>
<li>Bayesian statistics</li>
<li>Biostatistics</li>
<li>Longitudinal modeling</li>
<li>Real-world evidence</li>
<li>Biomedical machine learning</li>
<li>Parkinson's disease</li>
<li>Movement science</li>
<li>Reproducible research</li>
<li>Evidence provenance</li>
</ul>
</div>

<div class="profile-section">
<h3>What's Next</h3>
<p>
Reuben is continuing to work at the intersection of clinical research, Bayesian trial
design, biomedical machine learning, and reproducible evidence pipelines through his lab
at DePauw and collaborations in biopharma.
</p>
<p>
He is particularly interested in problems where quantitative methods can make a clinical
or development decision more transparent, reproducible, and easier to defend. OpenTrial
remains a learning-oriented research tool and is not validated for real-world clinical use.
</p>
</div>

</div>
</div>
</section>

<!-- ============= FOOTER ============= -->
<footer class="footer">
<div class="container footer-inner">
<div>
<div class="brand">
<span class="logo" aria-hidden="true">
<svg viewBox="0 0 100 100" width="28" height="28">
<rect width="100" height="100" rx="22" fill="url(#brandGrad)"/>
<text x="50" y="62" font-family="Inter,Arial" font-size="42" font-weight="800" text-anchor="middle" fill="white">DS</text>
</svg>
</span>
<span class="brand-text"><strong>DS4CABS</strong><small>Open data science for biopharma</small></span>
</div>
<p class="footer-note">
© <span id="year"></span> CABS, Chinese American Biopharmaceutical Society.
All project code is released under the licenses of the individual repositories.
</p>
</div>

<nav aria-label="Footer">
<h4>Explore</h4>
<a href="../index.html#featured">Featured</a>
<a href="../trending.html">Trending</a>
<a href="../team.html">Team</a>
<a href="../cohort.html">Cohorts</a>
<a href="../index.html#join">Apply</a>
<a href="../index.html#projects">Projects</a>
<a href="../index.html#donation">Donation</a>
</nav>

<nav aria-label="External">
<h4>Community</h4>
<a href="https://github.com/ds4cabs" target="_blank" rel="noopener">GitHub Org</a>
<a href="https://www.cabsweb.org/" target="_blank" rel="noopener">CABS Website</a>
<a href="https://github.com/ds4cabs/CABS-Data-Science-Summer-Internship-Program" target="_blank" rel="noopener">Internships</a>
</nav>
</div>
</footer>

<script src="../assets/js/projects.js"></script>
<script src="../assets/js/main.js"></script>
</body>
</html>