Source code for 'Recursive mutational robustness in cancer through intra- and intergenic compensation'

Contents

├── data/       ## available from zenodo (link below)
├── configs/    ## config.s
├── scripts/    ## analysis scripts
└── outputs/    ## outputs

Datasets

Dataset	Content	Source	Link
Tumors	Mutational perturbation and expression		This study*
	Pre-mRNA expression
Cell lines	Mutational perturbation and expression		This study*
	CRISPR perturbation and expression		This study*
Source data	Processed data for each analysis		This study*

*Data link

Usage

cd robustness_ms
uv sync ## https://docs.astral.sh/uv
source .venv/bin/activate

python scripts/run.py proc {analysis_name} {part_name} ## as given in the configs/analyses.yaml file

	Analysis	Related to
1	Pancancer survey	Fig 1
2	Upregulation	Fig 2
3	Robustness	Fig 3
4	Regulation	Fig 4
5	Implications	Fig 5

Citation

@article {Dandage2026.05.26.727768,
    author = {Dandage, Rohan and Hernandez-Corchado, Aldo and Madrigal, Ariel and Namini, Arsham Mikaeili and Wang, Jichen and Choi, Benedict and Goodarzi, Hani and Najafabadi, Hamed S.},
    title = {Recursive mutational robustness in cancer through intra- and inter-genic compensation},
    elocation-id = {2026.05.26.727768},
    year = {2026},
    doi = {10.64898/2026.05.26.727768},
    publisher = {Cold Spring Harbor Laboratory},
    URL = {https://www.biorxiv.org/content/early/2026/05/28/2026.05.26.727768},
    eprint = {https://www.biorxiv.org/content/early/2026/05/28/2026.05.26.727768.full.pdf},
    journal = {bioRxiv}
}