Drug Repurposing

This project computes the prediction probability of whether a compound will treat a disease. In another term, the project deals with repurposing the drugs to a disease, which is not a treatment at the moment.

Prerequisites

In order to run the assests you will need the following:

• Install Neo4j
• Python 3
• R

NoteBooks

1. Drug_Disease_HomogeneousPlot.py - Runs the homogeneous plot for the Drug and Disease pairs.
2. Drug_Gene_HomogeneousPlot.py - Runs the homogeneous plot for the Drug and Gene pairs.
3. Merging_Features.ipynb - Merges the features extracted from network and transforms them to transformed-features.csv.
4. Drug_Repurposing_Model.Rmd - Creates and run the model for predictions.

Components

• Data - the directory containing all the input csv files.
• Neo4j - the directory containing the data and code files to run the scripts in Neo4j.
• Viz - the directory containing all the network vizualizations

Authors

• Sarvesh Prattipati

Acknowledgments

• Daniel Himmelstein