ProSE

Protein Sequence Evolver

One-command library for generating sequence libraries for improving thermostability of an enzyme using state of the art deep learning methods

✨ What it does

Given

• Backbone – a reference PDB file
• Sequence – the corresponding amino-acid string (FASTA or plain text)
• Functional sites – one or more residue indices (0-indexed)

the sampler builds a diverse, high-quality library of candidate sequences in a single call

🏗️ Installation

Because all build-time metadata and dependencies live in pyproject.toml , you can install the package straight from the source tree:

# clone
git clone https://github.com/<your-username>/prose.git
cd prose

# install 
pip install -e .         

# ----- OR, if you use Poetry -----
poetry install

🧪 Sample

Acknowledgement

The development of this tool was made possible by a grant from Homeward Bio