COMPASS (Comprehensive Multi-omics Polycomb Analysis Scoring System) is a context-aware framework for prioritising candidate Polycomb target genes by integrating PcG-perturbation RNA-seq and H3K27me3 ChIP-seq evidence.
COMPASS converts heterogeneous transcriptomic and epigenomic evidence into a continuous, interpretable Polycomb Target Score (PTS), enabling gene prioritisation across tissues, cell types and disease contexts.
Polycomb target identification is often based on either chromatin occupancy or perturbation-responsive expression. However, these assays capture complementary but incomplete aspects of Polycomb regulation.
COMPASS addresses this by:
- scoring RNA-seq perturbation evidence and H3K27me3 ChIP-seq evidence independently;
- integrating evidence within biological contexts;
- applying biologically interpretable pattern weights;
- retaining evidence provenance and incomplete-evidence information;
- generating a continuous, context-specific Polycomb Target Score.
- Context-aware Polycomb target prioritisation
- Integration of perturbation transcriptomics and H3K27me3 evidence
- Interpretable scoring framework
- Support for incomplete single-modality evidence
- Evidence-traceable gene ranking
- Robustness, ablation and benchmark analysis modules
The main output is a gene-context level Polycomb Target Score (PTS).
A high PTS indicates strong available evidence for Polycomb-associated regulation in a defined context. It should be interpreted as prioritisation evidence, not proof of direct PcG binding or causal repression.
COMPASS/
├── data/ # input metadata and processed evidence tables
├── scripts/ # COMPASS scoring and analysis scripts
├── results/ # output scores, benchmarks and figures
└── README.md
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