diff --git a/src/compile/set.ts b/src/compile/set.ts
index 1cde584..ead769e 100644
--- a/src/compile/set.ts
+++ b/src/compile/set.ts
@@ -1,6 +1,13 @@
-import type { SetAST, VELOCITY_AST } from '../type';
+import type { ReferencesAST, SetAST, VELOCITY_AST } from '../type';
 import { applyMixins } from '../utils';
 import { Compile } from './base-compile';
+
+const POLLUTING_KEYS = new Set(['__proto__', 'constructor', 'prototype']);
+
+function isPollutingKey(key: string): boolean {
+  return POLLUTING_KEYS.has(key);
+}
+
 /**
  * #set value
  */
@@ -20,11 +27,20 @@ export class SetValue extends Compile {
     // not find local variable, return global context
     return this.context;
   }
+  private hasPollutingPropertyPath(ref: ReferencesAST): boolean {
+    return Boolean(ref.path?.some((exp) => exp.type === 'property' && isPollutingKey(exp.id)));
+  }
+
   /**
    * parse #set
    */
   setValue(ast: SetAST): void {
     const ref = ast.equal[0];
+
+    if (isPollutingKey(ref.id) || this.hasPollutingPropertyPath(ref)) {
+      return;
+    }
+
     let context = this.getContext(ref.id) as object;
 
     // @see #25
@@ -68,6 +84,11 @@ export class SetValue extends Compile {
         key = '';
       }
 
+      if (isPollutingKey(key)) {
+        // Return true to stop Array.prototype.some traversal without assigning.
+        return true;
+      }
+
       if (isEnd) {
         (baseRef as Record<string, unknown>)[key] = val;
         return true;
diff --git a/test/set.test.ts b/test/set.test.ts
index 866d8d6..1d0efb3 100644
--- a/test/set.test.ts
+++ b/test/set.test.ts
@@ -190,6 +190,45 @@ describe('Set && Expression', function () {
     });
   });
 
+  describe('prototype pollution protection', function () {
+    afterEach(function () {
+      delete (Object.prototype as Record<string, unknown>).polluted;
+      delete (Object.prototype as Record<string, unknown>).isAdmin;
+    });
+
+    it('does not set values through __proto__ references', function () {
+      render('#set($__proto__.polluted = "hacked")', {});
+
+      assert.equal(({} as Record<string, unknown>).polluted, undefined);
+    });
+
+    it('does not set values through constructor.prototype paths', function () {
+      render('#set($target.constructor.prototype.isAdmin = true)', { target: {} });
+
+      assert.equal(({} as Record<string, unknown>).isAdmin, undefined);
+    });
+
+    it('does not set prototype-polluting index keys', function () {
+      render('#set($target["__proto__"].polluted = "hacked")', { target: {} });
+
+      assert.equal(({} as Record<string, unknown>).polluted, undefined);
+    });
+
+    it('does not evaluate assigned values for prototype-polluting paths', function () {
+      let evaluated = false;
+
+      render('#set($__proto__.polluted = $markEvaluated())', {
+        markEvaluated() {
+          evaluated = true;
+          return 'hacked';
+        },
+      });
+
+      assert.equal(evaluated, false);
+      assert.equal(({} as Record<string, unknown>).polluted, undefined);
+    });
+  });
+
   it('set with foreach', function () {
     const tpl = `
 #foreach($item in [1..2])