diff --git a/Formula/registration-toolkit.rb b/Formula/registration-toolkit.rb
new file mode 100644
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--- /dev/null
+++ b/Formula/registration-toolkit.rb
@@ -0,0 +1,69 @@
+class RegistrationToolkit < Formula
+  desc "C++ utilities for image-to-image and image-to-mesh registration"
+  homepage "https://github.com/educelab/registration-toolkit"
+  url "https://github.com/educelab/registration-toolkit/archive/refs/tags/v1.8.0.tar.gz"
+  sha256 "e45e139d26b0f286e40af688f949337db8de4d44af6da3b6536a82ccf270994c"
+  license "GPL-3.0-or-later"
+  head "https://github.com/educelab/registration-toolkit.git", branch: "develop"
+
+  depends_on "cmake" => :build
+  depends_on "boost"
+  depends_on "eigen"
+  depends_on "fmt"
+  depends_on "itk"
+  depends_on "libtiff"
+  depends_on "opencv"
+  depends_on "spdlog"
+  depends_on "vtk"
+
+  # Upstream's CMake uses FetchContent for these transitive deps, each pinned
+  # to the commit listed in cmake/Build*.cmake. Homebrew traps live
+  # FetchContent calls, so we vendor them as resources and point the build at
+  # the pre-staged sources via FETCHCONTENT_SOURCE_DIR_<NAME>.
+  #
+  # Use git URLs with explicit revisions: GitHub/GitLab autogenerated tag
+  # tarballs are not byte-stable enough for sha256 pinning. Commit SHAs are.
+
+  resource "smgl" do
+    url "https://gitlab.com/educelab/smgl.git",
+        revision: "d74d76d121a18afab9b12dd9dc3d643f4e620ff1"
+  end
+
+  resource "bvh" do
+    url "https://github.com/madmann91/bvh.git",
+        revision: "66e445b92f68801a6dd8ef943fe3038976ecb4ff"
+  end
+
+  resource "libcore" do
+    url "https://github.com/educelab/libcore.git",
+        revision: "43666d4918a484e7e950fff7607865f78ff4b621"
+  end
+
+  resource "OpenABF" do
+    url "https://github.com/educelab/OpenABF.git",
+        revision: "3c1b52a02a15007d3dcb7746b08a4f3db0e7a0b6"
+  end
+
+  def install
+    resource("smgl").stage(buildpath/"_deps/smgl")
+    resource("bvh").stage(buildpath/"_deps/bvh")
+    resource("libcore").stage(buildpath/"_deps/libcore")
+    resource("OpenABF").stage(buildpath/"_deps/OpenABF")
+
+    system "cmake", "-S", ".", "-B", "build",
+                    "-DRT_BUILD_DOCS=OFF",
+                    "-DRT_BUILD_TESTS=OFF",
+                    "-DFETCHCONTENT_FULLY_DISCONNECTED=ON",
+                    "-DFETCHCONTENT_SOURCE_DIR_SMGL=#{buildpath}/_deps/smgl",
+                    "-DFETCHCONTENT_SOURCE_DIR_BVH=#{buildpath}/_deps/bvh",
+                    "-DFETCHCONTENT_SOURCE_DIR_LIBCORE=#{buildpath}/_deps/libcore",
+                    "-DFETCHCONTENT_SOURCE_DIR_OPENABF=#{buildpath}/_deps/OpenABF",
+                    *std_cmake_args
+    system "cmake", "--build", "build"
+    system "cmake", "--install", "build"
+  end
+
+  test do
+    assert_match "--log-level", shell_output("#{bin}/rt_register --help 2>&1")
+  end
+end